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EPIDEMICS
SARS lessons hang over China's fight against new virus
By Eva Xiao and Laurent Thomet
Beijing (AFP) Jan 23, 2020

Studies suggest role of bats, snakes in outbreak of China virus
Beijing (AFP) Jan 23, 2020 - A new strain of coronavirus that emerged in China may have originated in bats or snakes, according to genetic analysis of the virus that has so far killed 17 people.

The theories are based on examination of the genome sequence of the virus released by authorities in the wake of the outbreak, with two studies pointing to the likely role of bats in the outbreak.

One study, published Tuesday in the journal Science China Life Sciences, which is sponsored by Beijing's Chinese Academy of Sciences, looked at the relations between the new strain and other viruses.

It found the coronavirus that emerged from China's Wuhan was closely related to a strain that exists in bats.

"Bats being the native host of the Wuhan CoV (coronavirus) would be the logical and convenient reasoning, though it remains likely there was intermediate host(s) in the transmission cascade from bats to humans," the researchers from several institutions in China wrote in the paper.

That study did not speculate about which animal could have been an "intermediate host," but a second study published Wednesday in the Journal of Medical Virology identifies snakes as the possible culprit.

"To search for (a) potential virus reservoir, we have carried out a comprehensive sequence analysis and comparison. Results from our analysis suggest that snake is the most probable wildlife animal reservoir," the paper says.

The researchers caution that their conclusions require "further validation by experimental studies in animal models".

Neither study explained how the virus may have been transmitted from animals to humans.

But they could offer clues to Chinese authorities as they hunt for the source of the outbreak that has sickened hundreds of people in the country and has been confirmed as far afield as the United States.

The food market where the deadly virus surfaced offered a range of exotic wildlife for sale, including live foxes, crocodiles, wolf puppies, giant salamanders, snakes, rats, peacocks, porcupines, camel meat and other game.

Gao Fu, director of the Chinese centre for disease control and prevention, said in Beijing on Wednesday that authorities believe the virus likely came from "wild animals at the seafood market" though the exact source remains undetermined.

Severe Acute Respiratory Syndrome, or SARS, was linked to Chinese consumption of civet meat.

Many exotic species are still widely consumed in China or other Asian countries where they are considered a delicacy -- like the civet or some rats or bats -- or for purported health benefits unproven by science.

China's lockdown of an entire city to contain a virus outbreak stands in contrast to its handling of the deadly SARS crisis two decades ago, when it was criticised for being secretive and indecisive.

The new virus has killed 17 and infected more than 500 other people, with most cases found in Wuhan, the central city of 11 million people where outward flights and trains were indefinitely suspended on Thursday.

Like SARS (Severe Acute Respiratory Syndrome), China's new disease is contagious between humans, and is part of the same family of coronaviruses.

But unlike the 2003 SARS epidemic, when China drew international condemnation for covering up cases, Beijing is taking a starkly different approach to contain the new disease, experts say.

"Chinese authorities express the willingness to collaborate more transparently and more quickly than for (the) SARS outbreak," Antoine Flahault, deputy director of the Swiss School of Public Health, told AFP.

"This is (a) tremendously different attitude from 2003, although there are some pending questions regarding the exact number of cases and potential for underreporting."

The consequences of the information blackout during the Severe Acute Respiratory Syndrome (SARS) outbreak were keenly felt in China.

Nearly 650 people died across the mainland and Hong Kong from the disease.

During the SARS epidemic, the Chinese government took months to report the disease and initially denied World Health Organization (WHO) experts access to southern Guangdong province, where it originated.

But Beijing -- well-aware its response will be compared with the legacy of SARS -- seems determined not to repeat the mistakes of 2003 with the new coronavirus.

Even state media has admitted that "government agencies cannot hide information even if they want to" in the age of social media.

"The whole nation has sharpened its vigilance," said Zhong Nanshan, a renowned scientist at China's National Health Commission, state television reported Monday.

"The SARS epidemic of 17 years ago will not be repeated."

The disease has also spread to other countries, including the United States, South Korea, Thailand, and Japan.

- 'Effectively controlled' -

The Chinese government has published regular updates of the new virus since announcing its appearance at the end of December, the exact opposite to its response in 2003.

The country saw its first case of SARS in November 2002, but Beijing waited until February to officially acknowledge the disease, which it downplayed then as "effectively controlled".

Chinese authorities also repeatedly failed to coordinate with the WHO, which urged "full and open" reporting of cases.

In addition to Guangdong province, WHO experts were also blocked from accessing Beijing military hospitals with suspected SARS patients.

By early June 2003, more than 300 people in China had died from the disease, while another 5,329 remained infected.

In contrast, the head of the WHO, Tedros Adhanom Ghebreyes, on Wednesday hailed the "very, very strong measures" taken by China this time around.

He praised its openness about the current outbreak as "commendable".

Tedros spoke after the global body held a meeting on Wednesday to decide whether to classify the outbreak as a global health emergency. International experts were split and a new meeting will be held on Thursday.

- Transparency concerns -

In Washington, a US State Department official said on condition of anonymity that there have been "encouraging signs that the Chinese government has understood the gravity of this problem".

But the official added: "we're still concerned as far as transparency in the Chinese government."

Prioritising social stability over public health may have thwarted an earlier response to the Wuhan virus, said Dali Yang, a political science professor at the University of Chicago.

At the beginning of January, when Wuhan officials held an annual political meeting, the local government tried to "project this atmosphere of stability and calm in the region", he told AFP.

The mayor of Wuhan has also faced scrutiny for allowing a massive Lunar New Year banquet -- involving 40,000 families -- to take place on Saturday.

In an interview with CCTV Tuesday, he defended the decision by saying it was made before human-to-human transmission was officially confirmed on Monday.

There are also discrepancies between the number of infections reported by China and estimates from overseas researchers.

Scientists at the Imperial College in London published an estimate on Wednesday that 4,000 people have been infected in Wuhan -- much higher than the more than 500 cases reported by Chinese officials.


Related Links
Epidemics on Earth - Bird Flu, HIV/AIDS, Ebola


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EPIDEMICS
S. Korea confirms first case of SARS-like virus from China
Seoul (AFP) Jan 20, 2020
South Korea on Monday confirmed its first case of the SARS-like virus that is spreading in China, as concerns mount about a wider outbreak. A 35-year-old Chinese woman who flew in from Wuhan, the apparent epicentre of the outbreak, was confirmed to have the new coronavirus strain, the Korea Centers for Disease Control and Prevention (KCDC) said. She went to hospital in Wuhan on Saturday with symptoms of a cold and was prescribed medication before flying to Incheon airport on Sunday, where she wa ... read more

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