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McMaster Researchers Discover New Mode Of How Diseases Evolve
Hamilton, Canada (SPX) Feb 25, 2009 Researchers of the Michael G. DeGroote Institute for Infectious Disease Research have discovered a new way that bacteria evolve into something that can make you sick. The finding, published in the Feb. 16 issue of the Proceedings of the National Academy of Sciences, has implications for how scientists identify and assign risk to emerging diseases in the environment. The researchers found that bacteria can develop into illness-causing pathogens by rewiring regulatory DNA, the genetic material that controls disease-causing genes in a body. Previously, disease evolution was thought to occur mainly through the addition or deletion of genes. Brian Coombes, an assistant professor in the Department of Biochemistry and Biomedical Sciences, was the lead investigator of the study which involved researchers at McMaster University, the University of Melbourne, Australia and the University of Illinois at Chicago, USA. "Bacterial cells contain about 5,000 different genes, but only a fraction of them are used at any given time," Coombes said. "The difference between being able to cause disease, or not cause disease, lies in where, when and what genes in this collection are turned on. We've discovered how bacteria evolve to turn on just the right combination of genes in order to cause disease in a host. It's similar to playing a musical instrument - you have to play the right keys in the right order to make music." With infectious diseases on the rise, the McMaster finding has implications on how new pathogens are identified in the environment. Scientists currently monitor the risk of new diseases by assessing the gene content of bacteria found in water, food and animals. "This opens up significant new challenges for us as we move forward with this idea of assigning risk to new pathogens," Coombes said. "Because now, we know it's not just gene content - it is gene content plus regulation of those genes." Related Links McMaster University Epidemics on Earth - Bird Flu, HIV/AIDS, Ebola
Climate Change May Alter Malaria Patterns
Chicago IL (SPX) Feb 24, 2009Temperature is an important factor in the spread of malaria and other mosquito-borne diseases, but researchers who look at average monthly or annual temperatures are not seeing the whole picture. Global climate change will affect daily temperature variations, which can have a more pronounced effect on parasite development, according to a Penn State entomologist. |
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