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Killing 'zombie cells' cures anxiety in obese mice
by Tauren Dyson
Washington (UPI) Jan 4, 2019

Obesity increases the number of "zombie" cells, or senescent cells, inside the brain, causing more anxiety, new research says.

In a new study, researchers used senolytic drugs to decrease the number of zombie cells in mice brains. After taking drugs, the animals ended their anxious behavior, lost lipid cells in their brains and continued with normal neurological cell growth.

Senescent cells lay semi-dormant in various parts of the body, and eventually damage those parts. Some studies have even linked senescent cells to various conditions associated with aging like diabetes, osteoporosis and muscle weakness.

While the connection isn't quite clear, this current study's researchers know that obesity in humans and mice play a part in anxiety and other mood problems.

The researchers could spot anxiety in mice by using several validating tests. For one, anxious mice stay away from open areas, preferring to walk close to walls or corners. They also hesitate while walking through mazes, failing to complete the test.

Once the zombie cells were removed from their brains, the mice performed those tasks without anxiety.

As for humans, the National Institutes of Health says that more than 31 percent of Americans will experience an anxiety disorder at some point in their lives.

"Our data demonstrating a link between obesity, senescence and anxiety-like behavior provide critical support for the potential feasibility of administering senolytics to treat obesity-associated anxiety-like behavior, provided that clinical trials validate this approach," the study says.


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FLORA AND FAUNA
Engineers, zoologists reveal how gulls 'wing morph' for stable soaring
Toronto, Canada (SPX) Jan 03, 2019
A unique collaboration between University of British Columbia (UBC) zoologists and U of T Engineering's aviation expert Professor Philippe Lavoie provides new insights into how gulls configure their wing shape - known as wing morphing - to stabilize their flight. The findings could be used to design more efficient flying vehicles, including soaring drones for farming or environmental monitoring. Although a gliding bird's ability to stabilize its flight path is as critical as its ability to produce ... read more

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