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EPIDEMICS
China's virus strategy: a model for the world?
by Staff Writers
Beijing (AFP) March 22, 2020

China embarks on clinical trial for virus vaccine
Beijing (AFP) March 22, 2020 - China has started the first phase of a clinical trial for a novel coronavirus vaccine, records show, as the world's scientists race to find a way to combat the deadly pathogen.

It comes after US health officials said last week they had started a trial to evaluate a possible vaccine in Seattle.

The Chinese effort began on March 16 -- the same day as the US announcement -- and is expected to continue until the end of the year, according to a filing in the country's Clinical Trial Registry, dated March 17.

"Volunteers of the COVID-19 phase one trial have already started receiving the vaccine," a staff member involved in the government-funded project told AFP on Sunday.

The 108 participants, aged between 18 and 60, will be tested in three groups and given different dosages. They are all residents of the central city of Wuhan -- where the new coronavirus first emerged late last year.

As the COVID-19 pandemic rages and governments step up protection measures, pharmaceutical companies and research labs around the world are working at full tilt.

There are currently no approved vaccines or medication for the new disease, which has killed more than 13,000 people worldwide so far.

The vaccine trial announcements come amid an escalating feud between the US and China over the pandemic, with President Donald Trump enraging Beijing by speaking of the "Chinese virus".

China's nationalistic Global Times published an opinion piece last week noting "the development of a vaccine is a battle that China cannot afford to lose".

But the quest is expected to take time -- the US candidate vaccine may take another year to 18 months before becoming available.

An antiviral treatment called remdesivir, made by US-based Gilead Sciences, is already in the final stages of clinical trials in Asia and doctors in China have reported it has proven effective in fighting the disease.

But only randomised trials will allow scientists to know for sure if it really helps or whether patients would have recovered without it.

The head of the World Health Organization believes China's battle with the coronavirus offers a beacon of hope, but others question whether Beijing's strategy can be followed by other countries -- particularly Western democracies.

China has reported only one new local infection over the past four days, a seemingly remarkable turnaround given the chaos that surrounded the initial outbreak in the city of Wuhan.

While some experts caution against accepting Beijing's figures at face value, WHO chief Tedros Adhanom Ghebreyesus insisted China's success "provides hope for the rest of the world".

But China is a particular case -- a centrally-controlled, top-down, one-party authoritarian state that allows no dissent and can mobilise vast resources on a single issue.

- Close down and contain -

In January, China effectively shut down Wuhan and placed its 11 million residents in effective quarantine -- a move it then replicated in the rest of Hubei province, putting 50 million people in mass isolation.

Across the rest of the country, residents were strongly encouraged to stay at home.

Hundreds of millions of Chinese live in closed residential complexes where neighbourhood committees can police movement in and out -- meaning compliance could be closely monitored.

"Containment works," Sharon Lewin, professor of medicine at the University of Melbourne, told AFP. "Two weeks after the closure of Wuhan, which is exactly the incubation period, the number (of infections) started to drop."

Extreme social distancing and home quarantines have been used to differing degrees by a rising number of European countries, with some US states following suit.

But an Imperial College London study warned that while that strategy appeared to have succeeded to date in China, it carried "enormous social and economic costs" in the short and long term.

"The major challenge of suppression is that this type of intensive intervention package .... will need to be maintained until a vaccine becomes available (potentially 18 months or more)," it said.

If the intervention is relaxed, transmission rates "will quickly rebound", it added.

- Mass mobilisation -

At least 42,000 doctors and medical personnel were sent to Hubei province to shore up the province's health services which had, according to public health professor Zheng Zijie from Peking University, essentially "collapsed" under the strain of the fast-spreading epidemic.

Health experts from China's Red Cross are currently helping overwhelmed hospitals in Italy, which has fast overtaken China as the worst hit country in terms of coronavirus deaths.

China's ability to mobilise small armies of medical workers did not come with protection from contagion. More than 3,300 medical staff were infected across the country and 13 have died from COVID-19, according to health ministry figures published early March.

Government efforts in China were backed by an arsenal of propaganda, with messages repeated incessantly in the media and large street banners calling on citizens to be hygienic and stay home.

In an extraordinary effort -- trumpeted by state media -- two new hospitals with a total capacity of 2,300 beds were built in Wuhan within 10 days.

- Masks and checks -

In cities, it quickly became necessary to wear a mask as apartment blocks, businesses and even parks barred entry without one.

Widespread mask use may have helped slow the spread of the disease, "particularly when there are so many asymptomatic virus carriers", Zheng said.

During the crisis China produced up to 1.6 million N95 respirator masks per day, according to the official Xinhua news agency. These are considered the most effective protection, but need to fit correctly and be changed often.

To boost detection rates, temperature checkpoints were installed outside buildings and shops, or in public places.

"If it's higher than 37.3 degrees Celsius (99.1 Fahrenheit), you are put in isolation," one guard at the entrance to a park in Beijing told AFP.

And in the high-tech country where privacy is limited, many localities require citizens to show a QR code on their phone that rates them as "green", "yellow" or "red".

This assessment -- based on tracking of whether they visited a high-risk zone -- is now an entrance requirement for many businesses.

Government announcements have made clear that the coding system will remain in use in some form even after the pandemic subsides.


Related Links
Epidemics on Earth - Bird Flu, HIV/AIDS, Ebola


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Shares in Japanese firm Fujifilm Holdings sky-rocketed on Wednesday after Chinese authorities said a drug produced by the company could be effective for treating coronavirus patients. Fujifilm Holdings stock started the day untraded because of a glut of buy orders, before soaring 15.4 percent to 5,238 yen, the highest level allowed during trade for the day. China's ministry of science and technology said late Tuesday that some clinical trials have been completed on favipiravir - the main ingred ... read more

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