The euro continued to struggle on political uncertainty in Europe fuelled by shock EU election results, though the bloc's equities rebounded after two days of losses.
While a surge in Apple helped Wall Street reach another record, investors are growing increasingly nervous that the US central bank will hold off on cutting borrowing costs for an extended period as officials determine if prices have been brought under control.
Forecasts for the number of reductions the Fed will make in 2024 have been whittled down from six at the start of the year to just three at best now, following a string of figures indicating the labour market remains solid and the economy still in rude health.
Confidence took another blow Friday when the closely watched non-farm payrolls report came in far above expectations.
Focus is now on data due later Wednesday on last month's consumer price index, which eased in April after three straight above-estimate readings.
That will be followed by the conclusion of the Fed's latest policy meeting.
The bank is widely expected to stand pat on rates but its "dot plot" guidance, which shows officials' outlook for rates this year, is the main event. The last report tipped three cuts but speculation is swirling that bank boss Jerome Powell and others could reduce it further.
Anthony Saglimbene at Ameriprise said: "We expect Fed Chair Powell and company to maintain a position that stresses potential rate cuts remain contingent on the committee seeing further progress made on bringing down price pressures."
However, Dennis DeBusschere at financial services group 22V Research tipped the Fed to cut this year.
He said a study had found "63 percent of investors believe that the Fed will first cut because of a soft landing and that inflation is on a Fed-friendly path toward sub-three percent".
"So, there will be a cut because policy doesn't need to be as restrictive," he said.
Equity traders in Asia trod a cautious line, brushing off a record for the S&P 500 and Nasdaq in New York.
Tokyo, Hong Kong, Sydney, Wellington and Jakarta fell, while Shanghai, Singapore, Seoul, Mumbai, Bangkok and Taipei rose.
There was little reaction to data showing Chinese consumer prices rose slightly less than expected last month.
Investors are keeping tabs on an expected decision by the European Union on tariffs to be placed on Chinese electric vehicle makers, with Geely Auto and XPeng both down sharply in Hong Kong.
Beijing warned such a move would "harm" Europe's interests.
The euro remained stuck around five-week lows against the dollar after French President Emmanuel Macron called shock snap elections in reaction to his centrist party's rout by the far right in EU-wide polls.
The weekend's result was echoed across the bloc, sparking worries about unity at a time when it faces huge economic and security risks.
Macron's decision led ratings agency Moody's to warn it could lower France's credit score because it raises the risk of "political instability".
The euro's weakness mirrored a steep drop in European equities, with Paris losing more than one percent on each of the past two days.
Paris and Frankfurt both bounced back on Wednesday, while London also rose.
- Key figures around 0810 GMT -
Tokyo - Nikkei 225: DOWN 0.7 percent at 38,876.71 (close)
Hong Kong - Hang Seng Index: DOWN 1.3 percent at 17,937.84 (close)
Shanghai - Composite: UP 0.3 percent at 3,037.47 (close)
London - FTSE 100: UP 0.6 percent at 8,199.59
Euro/dollar: DOWN at $1.0741 from $1.0743 on Tuesday
Euro/pound: DOWN at 84.29 pence from 84.31 pence
Pound/dollar: UP at $1.2744 from $1.2739
Dollar/yen: UP at 157.31 yen from 157.11 yen
West Texas Intermediate: UP 0.8 percent at $78.52 per barrel
Brent North Sea Crude: UP 0.6 percent at $82.42 per barrel
New York - Dow Jones: DOWN 0.3 percent at 38,747.42 (close)
dan/pbt
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